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A second mechanism of PKA-independent incretin potentiation of glucose-stimulated insulin secretion (GSIS) involves cAMP-regulated guanine nucleotide exchange factor (cAMP-GEF) EPAC2

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Richter G, Feddersen O, Wagner U, Barth P, Goke R, G B

Signs that your gastric emptying delay has crossed into problematic territory include persistent nausea that prevents adequate food or fluid intake, visible abdominal distension, feeling full after just a few bites despite hours since your last meal, and severe acid reflux or excessive burping