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It plays a crucial role in maintaining cellular homeostasis and health

For treating disorders related to low levels of carnitine in hemodialysis patients, 1.8 grams of L-carnitine weekly to 3 grams daily or 30-120 mg/kg/week have been given by IV for 2 weeks to 12 months

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The role of local IGF-1 in chondrocyte proliferation is still somewhat unclear

In addition to the direct roles on hepatocytes, iron-generated ROS and lipid peroxidation by-products such as 4-hydroxy-2-nonenal (4-HNE) may induce the activation of KCs and HSCs [10, 21, 98, 99]