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Incretin antagonists While incretin agonists, such as GLP-1s, activate hormone receptors in the gut, other drugs known as antagonists take the approach of shutting down certain functions

Avosentan for overt diabetic nephropathy

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Patients prone to heart disease might fare best on medication that includes a GLP-1 component

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This might relate to GIPs potential effects on food reward pathways or metabolic signaling