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MK-801 interferes with nutrient-related signals for satiation

Those are reported numbers only

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While both medications are produced by Eli Lilly and function as GLP-1 receptor agonists, retatrutide offers a broader mechanism by targeting GCG receptors as well

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(2023, New England Journal of Medicine) Obesity Trial Study Design : Randomized, double-blind, placebo-controlled Phase 2 trial in adults with obesity or overweight