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doi: 10.1016/0016-5085(86)90936-4 Peptide YY and glucagon-like peptide-1 contribute to decreased food intake after Roux-en-Y gastric bypass surgery

Clinical trial data (Jastreboff et al., NEJM 2023

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A shot will lose very little, if any

Works for doses up to 5 mg at 10 mg/mL concentration

In much of the modern world, in which the population is now exposed to widely available and vastly excessive calories as well as to increasingly sedentary lifestyles 56,57,58,59 , these ancient survival-ensuring mechanisms are not merely irrelevant, but actually counter-productive and contribute to the obesity epidemic