Although a causal association with acute pancreatitis remains debated, observational studies suggest a higher incidence compared with placebo (Nieto et al., 2025
However, findings from trials like those of TRIUMPH-1 could open doors for its eventual approval and accessibility, allowing weight loss specialists to add it to their repertoire of medical interventions
(2022) Effect of tirzepatide versus insulin degludec on liver fat content and abdominal adipose tissue in people with type 2 diabetes (SURPASS-3 MRI): a substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial Chao Liao, et al
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The findings can provide some reassurance for pregnant women with unintentional first trimester exposure to GLP-1 RAs, however, further research is warranted to better understand the safety of these medications during pregnancy
