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Large, well-designed Phase II/III RCTs with distinct primary goals, uniform diagnostic criteria, and active comparators are needed
Financial terms include $350 million upfront, with up to $8.5 billion in development, regulatory, and commercial milestones, plus tiered royalties
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Vulnerability of oligodendroglia to glutamate: Pharmacology, mechanisms, and prevention
6,7,8 The antioxidant effect of uric acid can be manifested in the inhibition of cell death to protect nerves as well as profile support of NO-mediated vasodilation