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Pancreatic -Cell Calcium Channels The calcium channels in the plasma membrane of pancreatic -cells belong to the voltage-gated calcium channel family

The shear forces are strong enough to literally tear these bonds apart, causing the peptide to denature (unfold) or clump together into useless aggregates

The majority of GLP-1 leaving the intestinal venous circulation has already been cleaved by DP IV expressed in capillary surrounding gut L cells, which provides an estimated half-life of 12 minutes for intact GLP-1 in vivo [7]