Characterization of the universal BCR monoallelic HLA-DRB1 technology platform Upon generating the panel of monoallelic HLA-DRB1 cell lines with the universal BCR, we wanted to confirm the ability of the platform to bind, internalize, process, and load peptides for display on HLA-DRB1 from a wide variety of exogenous biotherapeutics
Age-related considerations Clinical trials included adults across a range of ages, but specific data on elderly populations is limited
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Visceral hypersensitivity, serotonin dysregulation, gut-brain axis dysfunction, and central/peripheral nervous system alterations are implicated in IBS-C pain, while FC pain is less studied and may be primarily linked to colonic distension and motility dysfunction
Table 1 Annotations features for glutathione transferase of Spirometra mansoni
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