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Dose-dependent fat loss was also observed, with statistically significant weight loss seen with the three highest doses compared to the placebo

These unmeasured confounders could account for the observed benefit to some extent, and the results should be cautiously interpreted

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They found that the predominant impact of SGLT-2 inhibitors is on cardiovascular outcome was driven predominantly by reduction in MACE, total death, HHF, MI, stroke, and CV death

Modified SELEX techniques, including mirror-image SELEX, photo-SELEX, toggle-SELEX, and microfluidic SELEX, optimize the selection process, augment aptamer stability, or improve functional diversity

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