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This may explain why the brain is particularly susceptible to aggregation-related neurodegenerative diseases

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Funding This work was supported by the Zhejiang Provincial Natural Science Foundation of China (LTGY24H030002), the National Key R&D Program of China (2022YFA1105603 and 2022YFC2304405), the Fundamental Research Funds for the Central Universities (2025ZFJH03 and 2022ZFJH003), the Zhejiang Provincial Key Research and Development Program (2019C03015), and the Shandong Provincial Laboratory Project (SYS202202)

However, dysfunctional mitochondria are associated with impaired neuronal function and associated neurodegenerative diseases (187)

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