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For example, while use of a relatively low overdose of 200 mg/kg APAP demonstrated protection against liver injury in cyclophilin D-deficient mice [96], only transient protection was achieved when cyclophilin was inhibited using cyclosporine A in vitro [94]

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The effects of topical tripeptide copper complex and helium-neon laser on wound healing in rabbits

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They get both through the blood supply

Further research is needed to assess safety, dosage, and potential side effects