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3.2.2 BNIP3/NIX mediated mitophagy NIX, a protein with 50% homology to BNIP3 (Matsushima et al., 1998), binds to the mitochondrial outer membrane through its carboxyl transmembrane domain, thereby initiating mitophagy under ischemic or hypoxic conditions

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However, a stratified analysis based on baseline characteristics indicated a trend suggesting that the treatment might help slow the progression of UV spots in specific subgroups

Without an approved Summary of Product Characteristics (SmPC), there is no authoritative basis for specifying diluent type, volume, or reconstitution technique for retatrutide