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HUVECs, in particular, act as semi-professional antigen-presenting cells, expressing major histocompatibility complex (MHC) class I constitutively and MHC class II in an inducible manner, thus potentially enhancing T-cell activation and distorting disease modelling (199, 200)

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Closely linked to this, MS techniques, particularly for complex formulations, are highly susceptible to matrix effects that can affect recovery and ionization efficiency of both the peptide and its impurities

For what the approved labeling actually warns about, the FDA-approved prescribing information is the authority

The harder lessons are methodological, and they shape what the next round of trials should look like

The availability of an orally-stable peptide formulation opens research avenues into oral drug delivery systems, enteric coating technologies, and comparative pharmacokinetics between administration routes