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As B12 is essential for the production of red blood cells and proper nervous system function, its deficiency can disrupt these processes and lead to symptoms like gastrointestinal discomfort and poor appetite, which may contribute to unintended weight loss

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NNMT is overexpressed in white adipose tissue during obesity, in senescent muscle stem cells during aging, and in certain cancer types

This deficiency is common, affecting approximately 6% of people under the age of 60 and 20% of people over the age of 60

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