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Infusion times are significantly longer than other IV protocols, typically requiring two to four hours due to the need for slow administration to minimize side effects such as chest tightness, nausea, and abdominal cramping

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However, results are limited by the small size, short duration, and lack of long-term follow-up [1][60]

Enzymatic degradation of DAMPs In diseases characterized by inflammation mediated by DAMPs, enzymatic degradation strategies exhibit substantial clinical potential through the targeting and clearance of pathogenic molecules

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