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[15] GLP-1 medications facilitate weight loss primarily through reducing appetite and caloric intake and slowing gastric emptying to prolong satiety
ClinicalTrials.gov (2016)
GLP-1 drug discovery began with Gila Monster studies, which identified a peptide (extendin-4) in their venom that eventually led to the development of GLP-1 drugs
Moreover, in addition to the direct action of GIP in adipose tissue to reduce serum triglyceride levels, GLP-1 may abolish the postprandial rise in triglyceride and free fatty acid concentrations by reducing intestinal absorption of dietary lipid, stemmed from the delayed gastric emptying (197, 198)
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