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This peptide works through multiple mechanisms: Modulates gene expression involved in tissue remodeling Increases collagen and elastin synthesis Promotes angiogenesis during tissue repair Shifts gene expression toward the TGF- pathway to reduce inflammation and restore connective tissue The copper component is critical because it activates lysyl oxidase enzymes that crosslink collagen and elastin fibers

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The formulation succeeded in significantly reducing levels of CXCL-1 compared to placebo group [188]

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Highlights 4 , 1126 (2013)