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Alcohol : Limit alcohol consumption, as it can worsen side effects of both medications and affect mental health

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A 2025 University of Michigan study found states with largest Medicaid reductions saw: Higher rates of buprenorphine treatment discontinuation Increased cash payments for addiction medications Greater overdose risks from interrupted MAT access This proved particularly concerning since only 5% of Indiana Medicaid enrollees with opioid use disorder received treatment prior to unwinding