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In this form of polyneuropathy, the first nerve fibers to malfunction are those most distant from the central nervous system, with symptoms such as pain and numbness felt symmetrically in the feet, and then traveling up the legs as the condition progresses

Side effects can include increased estradiol, fluid retention, or mood changes

Ignoring these conditions can lead to serious complications

The Journal of Pharmacology and Experimental Therapeutics issued an Expression of Concern in 2021 (PMID: 34551989) for the McCoy et al