Pylori infections damage intestinal structures responsible for B12 absorption
The protonmotive force generated thereby drives protons through the F 0 F 1 ATP synthase, allowing condensation of a phosphate group to ADP, with the formation of ATP [23]
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After 5 days, 1.3 and 3.7 log reductions in bacterial viability were recorded when treated with 100 nM and 1.0 M of auranofin, respectively (Harbut et al., 2015)
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If your goal is the gut itself, oral's low systemic bioavailability is largely irrelevant because the action is local