Hypoglycaemia Incidence of any hypoglycaemia (defined as plasma glucose 3.9 mmol/l) with tirzepatide did not differ vs placebo (ESM Fig
Gombik K, Detka J, Bobula B, Bk J, Kusek M, Tokarski K, Budziszewska B (2021) Contribution of hypothyroidism to cognitive impairment and hippocampal synaptic plasticity regulation in an animal model of depression
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doi:10.2147/CCID.S128339 Watanabe F, Hashizume E, Chan GP, Kamimura A
In women with PCOS, hyperandrogenism, insulin resistance, and adipose-derived inflammatory cues have been associated with altered neutrophil activation profiles, including increased oxidative stress, degranulation, and markers suggestive of neutrophil extracellular trap (NET) formation
In clinical practice, they do not cause weight gain and are weight neutral, with a very low incidence of hypoglycemia as a side effect