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All mice showed a physiological extracranial [ 18 F]-FDG distribution with normal uptake in the Harderian glands, brown adipose tissue, myocardium, kidneys, gastrointestinal tract and urinary bladder

treat ligaments (MCL/LCL), tendon insertions

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Behavioral measurements should primarily include the percentage of time spent in the open quadrant, the percentage of entries into the open quadrant, the number of times the animal peeks down from the edge of the platform while in the open or closed quadrant, and the number of stretch-attend postures from the closed quadrant to the open quadrant

In some embodiments, a high viscosity otic formulation or device described herein provides an apparent viscosity of from about 100,000 cP to about 1,000,000 cP