Finally, while rodent models demonstrate compelling proof-of-concept (e.g., SCFA supplementation ameliorates OA), the translatability of these findings to human physiology, with its greater complexity and longer disease course, is a significant hurdle that future research must overcome (30)
Intramuscular (IM) injections are a quick and efficient method for delivering medication, typically taking just a few seconds to administer
The average severity of pain in the NAC group was between 8 and 9 out of 10 before treatment and between 4 and 5 after treatment
YH: Data curation, Formal Analysis, Software, Writing review and editing
Moreover, an enormous amount of time, labor, and cost are needed to optimize and improvements needed to translate each stimulus-based NM from the preclinical to clinical stage apart from endogenous triggers such as pH and temperature, as this varies depending from one person to another
GSH-pull down assays show that GSH directly interacts with capsid precursors and mature virus made in the absence of BSO whereas capsid precursors produced under GSH-depletion do not bind to GSH
