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Therefore, we speculated that DMF could affect 2OG or 2HG levels to affect DNA methylation and revisited the initial LC-MS analyses which showed there are significantly reduced levels of 2HG, but not 2OG after DMF treatment (Fig

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This prolonged effect was correlated with both NEP 24.11 and mouse plasma degradation studies, suggesting an increased stabilization towards other peptidases present in the organism

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