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[9] However, the authors acknowledged significant limitations, including risk of bias, small sample sizes, and considerable heterogeneity across studies

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& Hsu, S.-M

R.et al (2019a)

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33-35 Although single studies evaluating the efficacy of metformin for treatment of hirsutism in patients with PCOS have shown potential benefits, 36-38 meta-analyses showed no significant effects of metformin compared to placebo or oral contraceptives and decreased benefits compared to spironolactone and flutamide