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B12 supplementation is appropriate for individuals with confirmed deficiency, vegans, older adults, those with malabsorption disorders, people who have had bariatric surgery, and those on long-term medications such as metformin or proton pump inhibitors

In October 2021, the drug manufacturer submitted a marketing authorisation application to the EMA and a priority review voucher to the US FDA for the regulatory approval of tirzepatide in type 2 diabetes, leading to an expected review time of 8 months from the date of submission [12]

They have two undisclosed ADC programs in PTCL and gastric cancer

realized that hydrolysis of the thiosuccinimide ring prevented this elimination

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