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As estrogen receptors are ubiquitously distributed, they can modulate cell proliferation, differentiation, and survival in several tissues and organs, including the central nervous system (CNS)

Compounds 14 and 15 (Figure 15) were shown to significantly suppress inflammatory responses in vivo when compared to piperine and the conventional drug indomethacin, without causing stomach damage

At least one study provides reassurance that this need not be a major concern

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What variables can you control to eliminate it