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HGF largely originate from mesenchymal cells which acts in a paracrine manner on epithelial cells that express the c-MET receptor

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Food and Drug Administration also says in its safety profiles of these drugs that they should not be taken during pregnancy, noting there is "insufficient data" available

This review focuses on exploring the mechanisms of mitophagy in ischemic heart disease, summarizing recent studies on the protective role of mitophagy, and highlighting promising therapeutic targets

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