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Gastrointestinal Effects GLP-1 medications have significant effects on the digestive system: They slow stomach emptying, increasing feelings of fullness They reduce gastric acid production They may help with inflammatory bowel diseases They enhance gut barrier protection They have anti-inflammatory effects in the digestive tract While these effects help with weight loss and blood sugar control, they can also cause side effects like nausea, vomiting, and diarrhea

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These patches aim to deliver medication continuously, maintaining steady drug levels whilst avoiding the need for weekly or daily injections

The incidence is slightly higher than with semaglutide (13%) due to tirzepatides dual GIP and GLP-1 receptor agonism, which creates more pronounced metabolic and autonomic nervous system shifts

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When blood sugar is normal, they stop working automatically