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Levels of GHK-Cu naturally decline with age, which may influence processes related to skin health, wound healing, immune balance, and cellular regeneration

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The gradual titration schedule helps minimize early side effects, and most patients who complete the titration phase tolerate the medication well long-term

Whilst attractive as a theory, it should, nevertheless, be borne in mind that the majority of the studies cited above have been carried out in rodents or have examined isolated islets/-cells under in vitro or ex vivo conditions, and whether a local pancreatic DPP-4/GLP-1 system plays an important role in normal human physiology or in the pharmacological effect of DPP-4 inhibitors is not clear

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