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Molecular insights into withaferin-A-induced senescence: bioinformatics and experimental evidence to the role of NFB and CARF

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The mechanisms likely involve immune modulation (microglia in ALS can adopt a neurodegenerative phenotype that might be restrained by microbial signals) and metabolic support (providing nutrients like nicotinamide or SCFAs to neurons and glia) [214, 218]

doi: 10.1159/000119325 31 VermeulenRScholteH

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