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This timing also reduces the chance that injection-related stress disrupts sleep, since anxiety about needles occasionally interferes with nighttime relaxation

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As illustrated in Figure 3, it exerts its effects via activation of G protein-coupled receptors (GPCRs) including GPR41 (FFAR3), GPR43 (FFAR2), and GPR109A (HCAR2), which are expressed on epithelial cells and immune cells (Moniri and Farah, 2021

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