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While they can be highly effective for many patients, they are not right for everyoneand choosing the right program, provider, and level of support matters

Journal of Translational Medicine

Therefore, in peri- and post-menopausal patients, rapid or substantial weight loss while on semaglutide may plausibly unmask or intensify GSM symptoms via endocrine and tissue-level changesalthough the specific contribution of semaglutide vs weight loss per se is not established

Circ Res (2012) 110(10):132235

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The triple agonists are the newer, more mechanistically ambitious class