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Importance of identifying novel pharmacological targets for ASD treatment The increasing prevalence of ASD with the deterioration of the many autistic cases and the absence of drugs that are successful in treating the core symptoms of this illness have contributed to a heightened sense of urgency regarding the search for treatments for these cases of neurodevelopmental conditions [57]

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One of the most effective methods to evaluate net retention, or at least the biologically readily available metal load, is to compare the levels of metals in urine before and after the administration of a pharmaceutical chelating agent such as CaNa 2 EDTA, DMSA, or DMPS [98]