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meanwhile, another RCT observed a reduction of epicardial adipose tissue (EAT) thickness and its glucose uptake in T2D patients with SGLT-2i treatment [24, 25]

In trials, the commonly reported side effects included nausea, diarrhea, vomiting, and constipation, and participants generally described them as mild to moderate

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Even a consistent daily deficit of 500 kcal would theoretically produce around 0.5 kg of fat loss per week a change that may be imperceptible on the scales when overlaid with day-to-day weight variation

The combination produces synergistic effects because the medications target different metabolic pathwaysmetformin improves insulin sensitivity while semaglutide reduces appetite and slows digestion