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In a controlled study with women showing signs of photoaging, a GHK-Cu facial cream used daily for 12 weeks led to visible reduction in wrinkle depth and fine lines, outperforming both placebo and even a vitamin K cream

After an additional twenty-four hours, media was exchanged with fresh DMEM +dFBS / RPMI +pyruvate +dFBS /McCoys 5A +dFBS that was incubated overnight at 5% CO 2 supplemented with 300 ng/mL of Dox (for HeLa and Caki-1 lenti lines)

Rosenzweig, A., Blenis, J

As there were no specifically suitable positive control drugs for protective roles in PE, we chose the ferroptosis inhibitor Fer-1 as our option

References Adamo SA (2004) How should behavioral ecologists interpret measurements of immunity