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Therefore, it is not clear whether GLP-1 RA directly improves mitochondrial function, reduces ER stress, and reduces neuroinflammation, or indirectly improves these mechanisms by lowering blood glucose and improving IR

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GSH binds these free radicals and relieves oxidative stress not just on the mitochondria, but on the rest of the cell

It has also been demonstrated that SLC39A14, a member of the ZIP protein subfamily, is induced during the early stages of adipogenesis, being associated with increased Zn uptake [126]

Rheumatology (Oxford) 47 , 15671570 (2008)

It also underscores that preclinical endpoints must be interpreted carefully before conclusions are drawn