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A 2020 systematic review found that short-term use may have benefits, but long-term use can elevate fasting TMAO.28 From a prevention standpoint in relation to a number of chronic diseases, we are already encouraging people to decrease intake of red meat, Lampe says

its practical, proven, and compassionate

As a compounding pharmacist, I find this encouraging because it shows there's active discussion around therapies that many patients and providers have been asking about

Rosenstock J, Fonseca VA, Gross JL, et al

Food & Drug Administration (FDA-c)

Some research protocols have explored every-other-day dosing, though this is less common and may result in more variable effects