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In the presence of peroxides, the selenolate form of GPX4 is oxidized to selenic acid, which is regenerated to its active form by two molecules of reduced GSH, converting lipid hydroperoxides into non-toxic lipid alcohols and generating oxidized GSH (16,9294)

These improvements are likely to increase patient compliance and improve their overall quality of life

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CK loss or inhibition amplifies ROS and arrhythmia susceptibility, while preserves CK

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