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More importantly, after long-term CCl4 treatment in Nrf2 gene knockout mice, liver fibrosis was severely intensified, and inflammation increased (Xu et al., 2008)

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Acetaminophen induces ER dependent signaling in mouse liver

The experimental protocol was approved by the IRB of Changping Laboratory (CPNL-IRB-0002-2, 21 June 2024)