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Emerging clinical data suggest that interventions targeting muscle physiology directly may play an important role in supporting women undergoing metabolic change

Barkovich, A

(PubMed) Folkers K, Osterborg A, Nylander M, Morita M, Mellstedt H

A 2025 JAMA Psychiatry trial (Hendershot et al.) tested lower-dose semaglutide over nine weeks and found reductions in some laboratory measures with smaller real-world effects, suggesting the higher 2.4 mg dose may matter

Complementary in-vivo evidence for a direct anti-inflammatory vascular action comes from the LIRAFLAME positron emission tomography / computed tomography (PET/CT) substudy [24]

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