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The GLP-1RA liraglutide significantly reduces the eosinophilia and the production of type-2 cytokines species like IL-5 and IL-13 in the respiratory tract, while GLP-1R signaling downregulates innate allergic inflammation [135]

The mechanism appears to involve multiple pathways: upregulation of growth factors like VEGF and EGF, modulation of the nitric oxide system, interaction with dopaminergic pathways, and direct effects on tissue regeneration

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