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~ AlphaMD Hormone Replacement Therapy (HRT) is a broad term that refers to treatments designed to restore hormones to healthy levels

A second reason to consider transition is if a patient experiences GLP-1 receptor desensitization, where the same dose produces progressively weaker appetite suppression

These drugs mimic a natural gut hormone (GLP-1) that stimulates insulin secretion, slows digestion, and reduces appetite

In those cases, a tiny blip of GLP1 can be enough to reset pathways without triggering heavy nausea or profound weight loss