GLP-1 medications work like an upgraded factory supervisor who coordinates multiple departments at once: Pancreas (Smart Insulin Release): Stimulates insulin only when blood sugar is high stops when sugar normalizes low risk of hypoglycemia (unlike older drugs) Brain (Appetite Control): Acts on hypothalamus & brainstem reduces food cravings food loses emotional grip Stomach (Slow Emptying): Delays gastric emptying smaller meals keep you full longer Liver (Reduced Sugar Output): Suppresses glucagon lowers excessive glucose release from liver improves fasting blood sugar (especially beneficial for insulin-resistant individuals, common in Indian populations) Beyond Blood Sugar (Multi-Organ Effects): GLP-1 receptors found in heart, blood vessels, kidneys, brain being studied for heart failure, kidney disease, fatty liver (NAFLD/NASH), Parkinsons, and Alzheimers GLP-1 Medications List: Names, Forms, and Costs in India (2026) Important note: Oral semaglutide (Rybelsus) is currently approved in India only for Type 2 diabetes, not for weight loss

The extension data shows that weight loss at the 12mg dose continued to accumulate between week 80 and week 104 without an obvious plateau
This makes it an appealing option for individuals seeking more impactful results
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Trulicity does not interact with grapefruit or grapefruit juice
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