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Same results were obtained on culture models, the P e values of ibuprofen were 0.28 and 0.53 10 6 cm/s across a porcine brain endothelial cell line and a rat primary brain endothelial based BBB models, respectively [71]

The acetylation of histones is dependent on the availability of acetyl-CoA (Sivanand et al., 2018), a central metabolite in multiple metabolic pathways (Sivanand et al., 2018)

for example, cell membrane transporter proteins are important in drug resistance because they alter drug transport

HR 0.84, 95% CI 0.481.48) (Table 5)

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