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In the treatment of children with inherited B12 metabolism and transport disorders, serum levels are maintained at around 7,500pmol/L without any side effects

PLoS ONE 12:e184709 Kim HW, Yu AR, Lee JW, Yoon HS, Lee BS, Park HW, Lee SK, Lee YI, Whang J, Kim JS (2022) Aconitate decarboxylase 1 deficiency exacerbates mouse colitis induced by dextran sodium sulfate

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Macan H, Uykimpang R, Alconcel M, et al

That is why G6PD-deficient RBCs are unable to withstand oxidative damage and are susceptible to destruction

doi: 10.1038/nature14344 100 WangWGreenMChoiJEGijnMKennedyPDJohnsonJKet al