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Some of the biggest cons of long-term semaglutide use is the high costs of covering the prescription costs and fees associated with doctors office visits

The reduction in lean body mass does not entirely equate to a decrease in skeletal muscle mass

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Other GLP1 receptor agonists, such as Trulicity (dulaglutide), Wegovy (also semaglutide but at a higher dose for weight loss), and Victoza (liraglutide), offer similar mechanisms but vary in dosing frequency, cost, and clinical indications

The consistency of patient-reported experiences suggests a meaningful impact on appetite regulation and food-related behaviors

Retatrutide, by adding the glucagon receptor, pushes results another 20-40% beyond Tirzepatide