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The insulin/IGF-1 signaling pathway seems to be an evolutionarily well-conserved mechanism involved in the regulation of longevity in species ranging from metazoans to mammals [1, 2]

In addition to decreasing oxidative stress in the brain, glutathione improves mental clarity and memory, as well as helps prevent the formation of amyloid plaques.Intracellular GSH levels are inversely related to cell viability under oxidative stress in cultured neurons

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doi: 10.1042/bj3330167, 12 BrooksG