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It represents a fundamentally different approach to metabolic intervention, one that addresses energy expenditure in addition to energy intake

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Use electrolyte supplements or drinks like Pedialyte to replenish lost minerals

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To minimize the potential risk for an adverse CV event in NSAID-treated patients, use the lowest effective dose for the shortest duration possible

Populations of particular concern based on mechanism and the absence of human data include: individuals with active or suspected malignancy (pro-angiogenic preclinical profile)